Nanodiscs (lipid nanoparticles)
ATR-FTIR, HPLC, ICP
Background & Research Interest
My background is in bioanalytical chemistry (mass spectrometry of membrane proteins and nanodiscs). As I start my research group, my interests are getting more and more nano focused! My goal is to make nanodiscs of varying lipid composition and examine the fluidity of the membrane in the disc through fluorescent probes. I am also interested in how changing the diameter of the nanodisc through use of longer scaffold proteins changes the fluidity of the membrane. Finally, should this prove a robust method for assessing fluidity, I am ultimately interested in incorporating protein or peptids into the nanodiscs and using the fluidity to tease out details of lipid preference.